This project introduces the hierarchical structure in the brain's large-scale networks. We started this project first by using negative BOLD response as a new tools to examine hierarchical structure of the Default mode network. We are currently investigating the hierarchical structure of the visual networks in the brain. The ultimate goal is to show that the functional connectivity networks are representative of lower-level neurophysiological processes which might not be directly related to task performance. Instead, they provide the required infrastructure for the task-based co-activation networks.
This project aims to investigate the neural and neurophysiological mechanisms underpinning negative BOLD response in fMRI signal. Although there is emerging evidence that sheds light on the mechanism underlying task-based positive BOLD response, the accompanying negative BOLD response is mainly unknown, even though studies investigating NBR started as early as the introduction of the BOLD-fMRI. One reason for this lack of progress is the possibility that brain regions exhibiting negative BOLD response for a specific task may have separate underlying mechanisms.Therefore they need to be investigated separately.
Weill Cornell Medicine Quantitative Neuroimaging Laboratory
413 East 69th Street
BRB 1504
New York, NY 10065
Phone: (646) 962-6771
Fax: (646) 962-0577
