Localization of 18F PET images with MRI Image
Localization and investigation of Beta Amyloid PET images is often done through a radiologist’s visual inspection. In this project, we use a multimodal rigid-body registration to register PET images with their corresponding structural MRI images. We use the inverse transform to bring the localization data of the structural image to the PET image. This allows for a more accurate measure of local and global amyloid accumulation.
Detecting the Slice-timing parameter
Slice acquisition timing parameter is an essential information which is required for any slice timing correction techniques. Slice timing correction shown to be beneficial in task-based fMRI studies with TR of longer than 1 second. Here we developed a technique to detect the slice timing parameter and implemented it with Matlab.
Cortical Thickness and ROI Analysis
We have created a semi-automated pipeline that uses FreeSurfer to extract the vertex-wise cortical thickness data. Two levels of iterative manual corrections in this pipeline ensures not only that cortical structures are accurately parcellated, but also that the sub-cortical structures are correctly segmented.
Native Space Analysis
Native space analysis is a way of circumventing the spatial normalization required in any group-wise comparison. In native space analyses each subjects neuroimaging data are analyzed in their own space using an accompanying T1 weighted scan.
fMRI Course
Dr. Razlighi teaches an fMRI course entitled: Functional Imaging of the Brain (BMEN E4840), offered every Spring semester through the Biomedical Engineering Department. This is a project based course and for the past 3 years at least one of the defined class projects has been accepted for publication.