Selective association between cortical thickness and reference abilities in normal aging.

TitleSelective association between cortical thickness and reference abilities in normal aging.
Publication TypeJournal Article
Year of Publication2016
AuthorsLee S, Habeck C, Razlighi Q, Salthouse T, Stern Y
JournalNeuroimage
Volume142
Pagination293-300
Date Published2016 Nov 15
ISSN1095-9572
KeywordsAdult, Aged, Aging, Aptitude, Cerebral Cortex, Cognitive Aging, Female, Humans, Magnetic Resonance Imaging, Male, Mental Processes, Middle Aged, Principal Component Analysis, Regression Analysis, Young Adult
Abstract

A previous study of reference abilities and cortical thickness reported that association between reference abilities and cortical thickness summarized over large ROIs suppressed was suppressed after controlling for mean cortical thickness and global cognition. In this manuscript, we showed that preserving detailed spatial patterns of cortical thickness can identify reference-ability-specific association besides the association explained by global cognition and mean cortical thickness. We identified associations between cortical thickness and 3 cognitive reference abilities after controlling for mean thickness, global cognition, and linear chronological age: (1) memory, (2) perceptual speed, and (3) vocabulary. Global cognition was correlated with mean overall thickness but also was found to have a regionally specific pattern of associations. Nonlinear associations between cortical thickness and cognition were not observed, neither were nonlinear age effects. Age-by-thickness interactions were also absent. This implies that all thickness-cognition relations and age associations are independent of age and that consequently no age range is inherently special, since brain-behavioral findings are invariant across the whole age range.

DOI10.1016/j.neuroimage.2016.06.041
Alternate JournalNeuroimage
PubMed ID27353567
PubMed Central IDPMC5159226
Grant ListR37 AG024270 / AG / NIA NIH HHS / United States
R01 AG024270 / AG / NIA NIH HHS / United States
R01 AG038465 / AG / NIA NIH HHS / United States
K01 AG051348 / AG / NIA NIH HHS / United States
K01 AG044467 / AG / NIA NIH HHS / United States
RF1 AG038465 / AG / NIA NIH HHS / United States